[Libre-soc-dev] woke up unable to speak 01dec2025

[Luke Kenneth Casson Leighton]

levels of IL-6 38.8 have a massive detrimental
effect on mitochondria as well as on red blood cell
production, explaining the constant tiredness,
and the mis-shapen RBCs.

https://www.sciencedirect.com/science/article/abs/pii/S1079979613002088

Abstract
Anemia
<https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/anemia>
of
inflammation or chronic disease
<https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/chronic-disease>
is
a highly prevalent form of anemia. The inflammatory cytokine
<https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/inflammatory-cytokine>
interleukin-6
(IL-6) negatively correlates with hemoglobin concentration in many disease
states. The IL-6-hepcidin antimicrobial peptide axis promotes
iron-restricted anemia; however the full role of IL-6 in anemia of
inflammation is not well-defined. We previously reported that chronic
inflammation
<https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/chronic-inflammation>
had
a negative impact on maturation of erythroid progenitors in a mouse model.
We hypothesized that IL-6 may be responsible for impaired erythropoiesis
<https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/erythropoiesis>,
independent of iron restriction. To test the hypothesis we utilized the
human erythroleukemia
<https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/erythroleukemia>
TF-1
cell line to model erythroid maturation and exposed them to varying doses
of IL-6 over six days. At 10 ng/ml, IL-6 significantly repressed
erythropoietin-dependent TF-1 erythroid maturation. While IL-6 did not
decrease the expression of genes associated with hemoglobin synthesis
<https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/hemoglobin-synthesis>,
we observed impaired hemoglobin synthesis as demonstrated by decreased
benzidine
<https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/benzidine>
staining.
We also observed that IL-6 down regulated expression of the gene SLC4a1
which is expressed late in erythropoiesis. Those findings suggested that
IL-6-dependent inhibition of hemoglobin synthesis might occur. We
investigated the impact of IL-6 on mitochondria. IL-6 decreased the
mitochondrial
membrane potential
<https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/mitochondrial-membrane-potential>
at
all treatment doses, and significantly decreased mitochondrial mass at the
highest dose.


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geometry: without it life is pointless
the fibonacci series: easy as 1 1 2 3
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